郑加麟（男，汉族），现任同济大学医学与生命科学部主任及医学院院长。
教育经历
1982年9月----1987年7月 徐州医科大学 临床医学 学士
1987年9月----1990年7月 徐州医学院和南京医科大学 神经药理学 硕士
1990年9月----1992年10月 上海交通大学医学院 神经药理学 博士生
工作经历
19 92年10月-1993年3月
1993年3月-1996年7月
美国内布拉斯加大学医学中心攻读药理学博士后
1996年7月-1997年5月
美国内布拉斯加大学医学中心病理学和微生物学博士后研究员
1997年5月-1999年7月
美国内布拉斯加大学医学中心病理学和微生物学系任讲师
1997年5月至今
美国内布拉斯加大学医学中心神经退行性疾病研究中心神经毒理学部主任
1999年7月-2003年6月
美国内布拉斯加大学医学中心病理学、微生物学和药理学助理教授
2000年9月至今
美国内布拉斯加病毒学研究中心（内布拉斯加大学林肯分校，内布拉斯加大学医学中心和克雷顿大学）研究员
2002年1月-2007年7月
美国内布拉斯加大学医学中心神经退行性疾病研究中心研究生教育部主任
2003年7月-2008年7月
美国内布拉斯加大学医学中心病理学、微生物学、药理学和实验神经科学副教授（终身教授）
2004年9月-2007年1月
美国国立卫生研究院（nih） zrg1 ndbg 专家组成员
2004年9月-2007年12月
美国内布拉斯加大学医学中心药理学和神经实验学系副主任
2004年
随美国内布拉斯加州长mike johanns商务代表团访问中国（翻译和助手）
2005年至今
xpharm杂志（爱思唯尔 science出版社）副主编
2005年至今
美国内布拉斯加大学医学中心亚太地区合作发展部（aprdp）主任
2005年3月
获05年美国内布拉斯加大学医学中心joseph p. gilmore杰出科研奖
2007年
随美国内布拉斯加州长dave heineman商务代表团访问中国（翻译和助手）
2007年1月至今
美国国立卫生研究院（nih）“神经氧化代谢和凋亡研究”专家组常任成员
2007年7月至今
美国内布拉斯加大学医学中心研究生院副院长（主管研究生教育和国际交流）
2008年7月至今
美国内布拉斯加大学医学中心病理学、微生物学、药理学和实验神经科学教授（终身教授）
2010年12月起
同济大学医学与生命科学部主任
2023年6月
入选国家自然科学基金委员会公布2023年度医学科学部基础科学中心和创新研究群体项目专业评审组组成名单。
相关文献
代表性科研论文(十篇)
1.whitney, n., peng, h., erdmann, n., tian, t, monaghan, d. and zheng, j. (2008). 钙permeable ampa receptors containing q/r-unedited glur2 directs human neural progenitor cells differentiation to neurons. faseb j. (in press) (pmid: 18383342).
2.tian, c., erdmann, n., zhao, j., cao, z., peng, h. and zheng, j. (2008). hiv-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. j. neurochem. 105: 994-1005 (pmid: 18088378)
3.peng, h. and whitney, n., wu, y, tian, t, dou, h, zhou, y and zheng, j. (2008). hiv-1-infected and/or immune-activated macrophage-secreted tnf-a affects human fetal cortical neural progenitor cell proliferation and differentiation. glia. 56 (8): 903-16 (pmid: 18403631).
4.cui, m., huang, y., zhao, y. and zheng, j. (2008). foxo3a transcription factor mediates cell 死亡 in hiv-1 infected macrophages. j. immunology. 180:898-906. (pmid: 18178829)
5.erdmann n, zhao j, lopez a, herek s, curthoys n, hexum t, tsukamoto t, ferraris d, zheng j. (2007). glutamate production by hiv-1 infected human macrophage is blocked by the inhibition of glutaminase. j. neurochem. 102:539-49. (pmid: 17596215)
6.huang, y., erdmann, n., peng, h., herek, s., davis, j., luo, x. t. ikezu, and j. zheng (2006). trail-mediated apoptosis in hiv-1-infected macrophages is dependent on the inhibition of akt-1 phosphorylation. j. immunology 177: 2304-2313. (pmid: 16887991)
7.zheng, j., 壮族, w., yan, n., kou, g., peng, h., mcnally, c., erichsen, d., cheloha, a., herek, s., shi, c. and shi, y. (2004). classification of hiv-1 mediated neuronal dendritic and synaptic damage using multiple criteria linear programming. neuroinformatics 2 (3): 303-26. (pmid: 15365193)
8.zheng, j., ghorpade, a., thylin, m.r., cotter, r. l., niemann, d., epstein, l., swartz, j. m., shepard, r. b., liu, x., nukuna, a., gendelman, 高爆弹 (1999). lymphotropic virions affect chemokine 捕手mediated neural apoptosis: implications for hiv-1-associated dementia. j. virol. 73 (10): 8256-8267. (pmid: 10482576)
9.zheng, j., thylin, m. r., ghorpade, a., xiong, h., persidsky, y., cotter, r., niemann, d., che, m., zeng, y., gelbard, h.a., shepard, r. b., swartz, j. m., gendelman, h. e. (1999). intracellular cxcr4 signaling, neuronal apoptosis, and the neuropathogenic mechanisms for hiv-1-associated dementia. j. neuroimmunol. 98:185-200, (pmid: 10430052)
10.zheng, j., zhang p., hexum, t.d. (1997). neuropeptide y inhibits chromaffin cell nicotinic receptor stimulated tyrosine hydroxylase activity through a receptor linked g-protein mediated process. 摩尔 pharmacol. 52: 1027-1033, (pmid: 9415712)
其他发表文献
1.zheng, j., huang, y., tang, k., cui, m., niemann, d., lopez, a., morgello, s. and chen, s. (2008). hiv-1-infected and/or immune-activated macrophages regulate astrocyte cxcl8 production through il-1beta and tnf-alpha: involvement of mitogen-activated protein kinase and protein kinase r. journal of neuroimmunology (in press).
2.peng h, kolb r, kennedy j and zheng j. (2007). differential expression of cxcl12 and cxcr4 during human fetal neural progenitor cell differentiation. j. neuroimmunol pharm 2: 251-258. (pmid: 18040858)
3.zheng, j. and che, s-d. neuroimmune 药理学 expanding in asia pacific rim. j. neuroimmunol pharm. 2(3):233-5. 2007
4.haorah, j., knipe, b., gorantla, s., zheng, j., and persidsky, y. (2007). 乙醇-induced blood-brain barrier dysfunction is mediated via 肌醇 1, 4, 5-triphosphate 捕手 (ip3r)-gated intracellular 一水合醋酸钙 release. j. neurochem. 100:324-36. (pmid: 17241155).
5.erdmann, n. b., whitney, n. p., zheng, j. (2006). potentiation of excitotoxicity in hiv-1 associated dementia and the significance of glutaminase. clinical 神经科学 res. 6: 315-328. (pmid: 18059978)
6.peng, h., erdmann, n., whitney, n., dou, h., gorantla, s., gendelman, 高爆弹, ghorpade, a. and zheng, j. (2006). hiv-1-infected and/or immune activated macrophages regulate astrocyte sdf-1 production through il-1b. glia; 54:619-29. (pmid: 16944452)
7.yi, h., zhen, y., jiang, l., zheng, j. and zhao, y (2006). the phenotypic characterization of naturally occurring regulatory cd4+cd25+ t cells. cellular \u0026 molecular immunology 3: 189-195. (pmid: 16893499)
8.peng, h., huang, y., duan, z., erdmann, n., xu, d., herek, s., and zheng, j. (2005). cellular iap1 regulates trail-induced apoptosis in human fetal cortical neural progenitor cells. j. neurosci. res. 82: 295-305. (pmid: 16180223)
9.huang, y., erdmann, n., zhao, j. and zheng, j. (2005). the signaling and apoptotic effects of tnf-related apoptosis-inducing ligand in hiv-1 associated dementia. neurotoxicity research 8: 135-148. (pmid: 16260391)
10.huang, y., erdmann, n., peng, h., zhao, y. and zheng, j. (2005). the role of tnf-related apoptosis-inducing ligand in neurodegenerative diseases. cellular and molecular immunology 2:113-122. (pmid: 16191417)
11.kaul, m., zheng, j., okamoto, s., gendelman, he and lipton, sa (2005). hiv-1 infection and 艾滋病: consequences for the central nervous system. cell 死亡 and differentiation. 12 suppl 1:878-92. (pmid: 15832177)
12.deshpande, m., zheng, j., borgmann, k., persidsky, r., wu, l., schellpeper, c. and ghorpade, a. (2005). role of activated astrocytes in neuronal damage: potential links to hiv-1-associated dementia. neurotoxicity research 7 (3): 183-192. (pmid: 15897153)
13.peng, h., huang, y., rose, j., erichsen, d., herek, s., fujii, n., tamamura, h. and zheng, j. (2004). stromal cell-derived factor 1 mediated cxcr4 signaling in rat and human cortical neural progenitor cells. journal of 神经科学 research 76: 35-50. (pmid: 15048928)
14.ryan, l., peng, h., erichsen, d., persidsky, y., zhou, y., gendelman, 高爆弹 and zheng, j. (2004). links between tumor necrosis factor related apoptosis inducing ligand mediated human neuronal apoptosis and hiv-1 associated dementia. j. neuroimmunol. 148 (1-2): 127-139. (pmid: 14975593)
15.ryan, l., brester, m., bohac, d., morgello, s. and zheng, j. (2004). upregulation of soluble tnf 捕手 two in plasma of hiv seropositive individuals who use opiates. 艾滋病 research and human retroviruses. 20 (1): 41-45. (pmid: 15000697)
16.zhao, j., lopez, a. l., erichsen, d., herek, s., cotter, r. l., curthoys, n. p. and zheng, j. (2004). mitochondrial glutaminase enhances extracellular glutamate production in hiv-1 infected macrophages: linkage to hiv-1 associated dementia. journal of neurochemistry 88: 169-180. (pmid: 14675161)
17.ikezu, t., luo, x., weber, g. a., zhao, j., mccabe, l., buescher, j.l., ghorpade, a., zheng, j. and xiong, h. (2003). amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sapp and ab mediated neurotoxicity. j. neurochem. 85: 925-34. (pmid: 12716424)
18.erichsen, d., lopez, a.l., peng, h., niemann, d., williams, c., bauer, m., morgello, s., cotter, 自由欧洲电台, ryan, l.a., ghorpade, a., gendelman, 高爆弹 and zheng, j. (2003). neuronal injury induced fractalkine production: relevance to hiv-1 associated dementia. j. neuroimmunol. 138: 144-155. (pmid: 12742664)
19.luo, x., weber, g., zheng, j., gendelman, 高爆弹 and ikezu, t. (2003). c1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of alzheimer's disease. j. neuroimmunol. 135: 62-71. (pmid: 12576225)
20.xiong, h., boyle, j., winkeibauer, m., gorantla, s., zheng, j., ghorpade, a., persidsky, y., carlson, k.a. and gendelman, 高爆弹 (2003). inhibition of long-term potentiation by interleukin-8: implication for hiv-1-associated dementia. j. neurosci. res. 71: 600-607. (pmid: 12548717)
21.zheng, j., zhou, g., hexum, t. d. (2000). neuropeptide y secretion from bovine chromaffin cells inhibits cyclic amp accumulation. life sci. 67: 617-625. (pmid: 12659167)
22.cotter, 自由欧洲电台, williams, c., ryan, l., lopez, a., peng, h., and zheng, j. (2002). fractalkine and brain inflammation: implications for hiv-1-associated dementia. j. neurovirology. 8: 585-98. (pmid: 12476352)
23. ryan, l., cotter, 自由欧洲电台, zink, w.e., gendelman, 高爆弹, zheng, j. (2002). macrophage, chemokines and neuronal injury in hiv-1 associated dementia. mol. cell. biol. 48 (2): 137-150. (pmid: 11995633)
24.ryan, l., zheng, j., brester, m., bohac, d., hahn, f., anderson, j., ratanasuwan, w., gendelman, 高爆弹, swindells, s. (2001). plasma soluble cd14 and tnf-a 捕手 two levels correlate with cognitive dys函数 during hiv-1 infection. j. infec. dis. 184(6): 699-706. (pmid: 11517430)
25.zheng, j., thylin, m.r., persidsky, y., williams, c. e., cotter, 自由欧洲电台, zink, w., ryan, l., ghorpade, a., lewis, k., gendelman, 高爆弹 (2001). hiv-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise. neuro. res. 3(5): 461-484. (pmid: 14715459)
26.zheng, j., thylin, m.r., cotter, r. l., lopez, a. l., ghorpade, a., persidsky, y., xiong, h., leisman, g.b., che, m., gendelman, 高爆弹 (2001). hiv-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: relevance for hiv-1-associated dementia. neuro. res. 3(5): 443-459. (pmid: 14715458)
27. jiang, z.-g., piggee, c., heyes, m.p., murphy, c., quearry, b., bauer, m., zheng, j., gendelman, 高爆弹, markey, s.p. (2001). glutamate is a mediator of neurotoxicity in secretions of activated hiv-1-infected macrophages. j neuroimmunol. 117: 97-107. (pmid: 11431009)
28. cotter, r., zheng, j.*, che, m., niemann, d., liu, y., he, j., thomas, e., gendelman, 高爆弹 (2001). regulation of hiv-1 infection, b-chemokines production and ccr5 expression in cd40l-stimulated macrophages: immune control of viral entry. j. virol. 75:4308-4320. (*corresponding author) (pmid: 11287580)
29.zhang, p., zheng, j., bradley, m. e., hexum, 旅行者腹泻 (2001). atp stimulated cyclic amp formation in bovine chromaffin cells is enhanced by neuropeptide y. (evolution and pleiotropic function of npy and related peptides). peptides 22: 439-444. (pmid: 11287099)
30.persidsky, y., limoges, j., rasmussen, j., zheng, j., gearing, a., gendelman, h. e. (2001). reduction in glial immunity and neuropathology by a platelet activating factor antogonist and a matrix metalloproteinase and tnfa inhibitor in scid mice with hiv-1 脑炎 j. neuroimmunol. 114: 57-68. (pmid: 11240016)
31.yeh, m. w., kaul, m., zheng, j., nottet, B病毒l.m., thylin, m.r., gendelman, 高爆弹, lipton, 永恒沉睡 (2000). cytokine-stimulated but not hiv-infected human monocytes-derived macrophages produce neurotoxic levels of l-cysteine. j. immunol. 164: 4265-4270. (pmid: 10754324)
32.zhang, p., zheng, j., vorce, r. l., hexum, t. d. (2000). identification of an npy-y1 receptor subtype in bovine chromaffin cells. regul. pept. 87: 9-13. (pmid: 10710282)
33.wang, j., wang, l., zheng, j., anderson, j.l., toews, m.l. (2000). identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the 仓鼠 alpha-1b adrenergic receptors. 摩尔 pharmacol. 57: 687-694. (pmid: 10727513)
34.xiong, h., zeng, yong-chun, lewis, t., zheng, j., persidsky, y., gendelman, 高爆弹 (2000). hiv-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for hiv-1-associated dementia. j. neurovirol. 6 (suppl 1): s14-s23. (pmid: 10871761)
35.persidsky, y., zheng, j., miller, d., gendelman, 高爆弹 (2000). mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during hiv-1 associated dementia. j. leuk. biol. 68: 412-421. (pmid: 10985259)
36.cotter, r., burke, w., potter, j., zheng, j., gendelman, h. e. (1999). new insights into the neurodegenerative process of alzheimer’s disease: role of microglia-associated inflammation and neurotoxicity. j. leuk. biol. 65: 416-427.
37.zink, w. e., zheng, j., persidsky, y., poluektova, l., gendelman, 高爆弹 (1999). the neuropathogenesis of hiv-1 infection. fems immunol. med. micro. 22: 233-241.
38. zhang, p., zheng j., hexum, 旅行者腹泻 (1999). bibp 3226 inhibition of nicotinic 捕手 mediated chromaffin cell secretion. euro. j. pharmacol. 362: 121-125. (pmid: 9874161)
39.xiong, h., zeng, y. c., zheng, j., thylin, m. gendelman, h.e. (1999). soluble hiv-1 infected macrophage secretory products mediate blockade of long-term potentiation: a mechanism for cognitive dysfunction in hiv-1-associated dementia. j. neurovirology 5: 519-528. (pmid: 10568889)
40.xiong, h., zheng, j., thylin, m.r., gendelman, 高爆弹 (1999). unraveling the mechanisms for neurotoxicity in hiv-1 associated dementia: inhibition of neuronal synaptic transmission by macrophage secretory products. 艾滋病 res. hum. retrov. 15: 57-63. (pmid: 10024053)
41.swindells, s., zheng, j., gendelman, 高爆弹 (1999). hiv-1 associated dementia: new insights into therapeutics and disease pathogenesis interventions. 艾滋病 patient care and stds 13(3): 153-163. (pmid: 10375263)
42.xin, s., zheng, j., bian, c., qin, w. (1999). effects of l-tetrahydropalmatine on decreasing blood 压强 and improving coronary artery circulation. chinese j. of modern applied 药学 16 (2): 8-10.
43.gendelman, 高爆弹, zheng, j., coulter, c.l., ghorpade, a., che, m., thylin, m.r., rubocki, r., persidsky, y., hahn, f., reinhard, j., swindells, s. (1998). suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency 病毒associated dementia. j. infec. dis. 178: 1000-1007, (pmid: 9806027)
44.zheng, j., gendelman, h.e. (1997). the hiv-1 associated dementia complex: a metabolic encephalopathy fueled by viral replication in mononuclear phagocytes. curr. opin. neurol. 10: 319-325, (pmid: 9266156)
45.wang, j., zheng, j., anderson, j.l., toews, m.l. (1997). a mutation in the hamster alpha-1b adrenergic 捕手 that differentiates two steps in the pathway of receptor internalization. 摩尔 pharmacol. 52: 306-313, (pmid: 9271354)
46. zheng, j., zhang, p., toews, m., hexum, 旅行者腹泻 (1997). neuropeptide y enhance atpinduced formation of 肌醇 磷酸盐 in chromaffin cells. biochem. biophys. res. comm 239: 287-290, (pmid: 9345312)
47.yao, b., ge, xq, zheng, j., qin, w., bian, c.f. (1996). effects of m1 and M2 捕手 agonists and blockers on dog respiration. acta pharmacologic sinica (zhongguo yao li xue bao) 17(3): 267-70, (pmid: 9812755)
48.zheng, j., morrisett, 类风湿性关节炎, zhu, j., hexum, 旅行者腹泻 (1995). neuropeptide y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic 捕手 ion channel. j. pharmacol expt'l. ther. 274(2): 891-897, (pmid: 7543575)
49. ge, xq, zheng, j., qin, w., bian, c.f. (1995). inhibitory effect and mechanism of scopolamine on respiration. acta physiologica sinica 47(4): 397-402, (pmid: 7481883)
50.hexum, 旅行者腹泻, zheng, j., zhu, j. (1994). modulation of chromaffin cell secretion by neuropeptide y. j pharmacol exp ther. 271: 61-66, (pmid: 7965758)
51.yao, b., zheng, j., qin, w., bian, c.f. (1994). inhibitory effect of 6 beta-acetoxy nortropane on respiration. yao-hsueh-hsueh-pao 29(7): 497-501, (pmid: 7976358)
52.zheng, j., bian, c.f., and yu, a.y. (1992). muscarinic 捕手 subtypes in respiratory center and their functions. acta pharmacologic sinica (zhongguo yao li xue bao) 13(4): 349-354, (pmid: 1456058)
53. mu, y., chen, y., chu, y., zheng, j., zhang, m. (1992). radioimmunoassay of gastric mucosal pges in portal hypertensive rats with cirrhosis. acata acad. med. xuzhou 12(4): 299-303.
54.zheng, j., bian, c.f. (1990). effect of 6b-an on respiration, eeg and heart rate in 兔形目 acta acad. med. xuzhou 11: 12-15.
55.zheng, j., bian, c.f. (1990). effect of af-dx 116 on respiration, eeg and heart rate in rat. acta acad. med. xuzhou 11: 39-42.
56.zheng, j., yu, a.y., bian, c.f. (1990). characterization of muscarinic receptor subtypes in the rat brain stem. acta acad. med. xuzhou 11: 5-10.
57.zheng, j., bian, c.f., ge, x.c. and yu, a.y. (1990). relationship between muscarinic receptor subtypes and the changes in eeg in rabbits. acta acad. med. xuzhou 10: 281-285.
58.bian, c.f., zheng, j., yi, x.x. and hong, x.m. (1990). effects of anticholinergic drugs on respiratory center. asia pacific j. pharmacal 5 (suppl): 12.参加编著的书籍 1.cotter, r., zheng, j., gendelman, h.e. (1998). the role of mononuclear phagocytes in neurodegenerative disorders: lessons from multiple sclerosis, alzheimer’s disease and hiv-1 associated dementia. in: advances in neurodegenerative disorders vol.2, alzheimer’s and aging, edited by j marwah and h teitelbaum, prominent press, scottsdale, AZ 203-241.
2.carlson, k. a., cotter, 自由欧洲电台, williams, c.e., branecki, c.e., zheng, j., gendelman, 高爆弹 (2002). the role of mononuclear phagocytes in the pathogenesis of alzheimer’s disease. in: the macrophage 2nd ed., edited by b burke and c lewis, oxford medical publications, oxford.
3.anderson, e., ryan, l., xiong, h., swindells, s., zheng, j., and gendelman, h.e. (2004). neural immunity and human immunodeficiency 病毒1-associated dementia. page 547-559. in blood-spinal cord and brain barriers in health and disease, eds by h. s. sharma and j. westman, elsevier science, usa.
4.zheng, j., peng, h., rose, j. and herek, s. (2005). neurogenesis and its links to brain development, developmental therapeutics and the pathogenesis of neurodegenerative disorders including hiv-1 associated dementia. in the neurology of 艾滋病, second edition, eds by gendelman, 高爆弹, grant, i., lipton, s.a., everall, i., and swindells, s. page 239-253, oxford university press, oxford.
5.gendelman, h.e., anderson, e., melendez, l., and zheng, j. (2006) chemokines and their receptors and the neuropathogenesis of hiv-1 infection. in in vivo models of hiv disease and control. 电子数据系统 h. friedman, s. specter and m. bendinelli, springer, new york.
6.erdmann, n., huang, y. and zheng, j. (2007). the relevance of chemokines and cytokines to the pathogenesis of hiv-1 associated dementia. in the neuro-艾滋病, eds by paul shapshak and alireza minagar, nova science publisher, 特库摩, hauppauge, ny. (in press)
7.peng, h., whitney, n.p., tang, k., toews, m. and zheng, j. (2008) stem cells and neurogenesis and its links to brain development and pathogenesis of neurodegenerative disorders. in the neuroimmue 药理学 eds by tsney ikezu and howard e. gendelman, page 151-182, springer publisher, inc, ny.
8.huang, y., erdmann, n., hexum, t. and zheng, j. (2008). the relevance of chemokines, cytokines and growth factors to the pathogenesis of neurodegenerative disorders. in the neuroimmue 药理学 eds by tsney ikezu and howard e. gendelman, page 183-205, springer publisher, inc, ny.
参与团体
美国神经科学协会，美国微生物协会，国际神经化学协会，国际神经病毒协会，美国免疫协会，国际神经毒性协会，国际神经免疫药理学协会，国际神经免疫协会
研究项目
国家级与社会研究项目（美国）
1. HUAWEI P20 rr15635-01 (铜)
principle investigator \u0026 center director: wood, c
dates: 9/01/05 to 04/30/10 (year 6-10)
nih/ncrr（美国国立卫生研究院/ncrr）
“cxcr4, neurogenesis and hiv-1 associated dementia”
该项目主要研究cxcr4在hiv-1中的神经病理学作用。
project 2 leader: 郑加麟2. 1 r01 ns 41858-01
principle investigator: 郑加麟
dates: 06/01/05-04/30/10 (year 5-9)
nih/ninds（美国国立卫生研究院/ninds）
"trail and glutaminase: neurotoxic link in hiv dementia "
该项目的主要目的是研究hiv-1相关痴呆（had）trail与谷胺胺酶介导的神经损伤。表明病毒学、免疫学和受体药理学在研究had机制中的相互关系.
3. 1 r01 ns 61642
principle investigator: 郑加麟
dates: 07/01/08-06/30/13 (year 1-5)
nih/ninds（美国国立卫生研究院, /ninds）
"sdf-1 and neurogenesis in hiv-1 associated dementia"
4. po1ns 43985-01 (PPG)
principle investigator: gendelman, 高爆弹
dates: 05/15/03-04/30/13 (year 5-10)
nih/ninds（美国国立卫生研究院/ninds）
“neuronal chemokines and macrophage activation”
该项目的主要目的是研究神经趋化因子（fractalkine）在神经损伤中的反应。fractalkine介导的吞噬活动将被定义。一种特定的基因芯片技术将被用来判定hiv-1感染和fractalkine介导激活吞噬产物的表达和调节。
role: project 1 leader: 郑加麟
5. 1r21mh083525-01
principle investigator: 郑加麟
dates: 4/1/08-3/31/10
nih/nimh（美国国立卫生研究院/nimh）
“hiv-1 clade diversity and macrophage mediated neurotoxicity in hiv-1 dementia”
6. guilford pharmaceuticals r\u0026 d grant
principle investigator: 郑加麟
dates: 8/15/04-9/14/08
guilford pharmaceuticals
title: “the effect of glutaminase inhibitors in hiv infection of macrophages”
7. 1ro1 ns41862-01
principle investigator: xiong, h.
dates: 06/01/05-03/30/10
nih/ninds（美国国立卫生研究院/ninds）
"macrophages, neuronal k+ channels and hiv-1 dementia”
该基金研究hiv-1感染的单核吞噬细胞影响神经突触传导及可塑性与nmda可塑性及nmda受体功能。
role: co-investigator: 郑加麟
8. ro1 aa015913-01a
principle investigator: persidsky, y.
dates: 10/1/05-9/30/10
nih/ninds（美国国立卫生研究院/ninds）
“ppar-g mediated neuroprotection against hiv-1 and alcohol cns injury”
该基金用以研究ppar-g介导的抵抗hiv-1和乙醇引起的中枢神经损伤中的神经保护机制
role: co- investigator: 郑加麟
已完成的研究项目
1. HUAWEI P20 rr15635-01 (铜)
principle investigator \u0026 center director: wood, c
dates: 10/01/00 to 08/30/05 (year 1-5)
nih/ncrr（美国国立卫生研究院/ncrr）
“cellular mechanisms for hiv-1 induced neuronal injury”
role: project 1 leader: 郑加麟2. 1 r01 ns 41858-01
principle investigator: zheng, j.
dates: 06/01/01-05/31/05 (year 1-4)
nih/ninds（美国国立卫生研究院/ninds）
"macrophage activation, chemokines, and hiv dementia"
role: principle investigator: 郑加麟
3. t32ns07488
principle investigator: gendelman, 高爆弹
dates: 7/1/02－6/30/07
nih/ncrr（美国国立卫生研究院/ncrr）
“training program in neurovirology”
role: co-principle investigator: 郑加麟
研究成果
2022年8月3日消息，同济大学附属同济医院郑加麟教授、夏骁寰研究员和同济大学附属上海市肺科医院袁平副研究员团队合作，使用简易精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)问卷分析了同济大学附属上海市肺科医院肺循环科收治315例肺动脉高压患者和315例对照者的认知障碍表现，并研究了认知功能功能障碍与肺动脉高压发病风险、严重程度和临床恶化事件之间的关系。结果提示肺动脉高压患者存在认知障碍，该障碍与疾病的严重程度显著相关，MMSE和MoCA总评分可独立预测发病风险和预后表现。该研究工作首次发现了肺动脉高压疾病进展与神经认知功能变化间的关系，提出了肺脑轴复杂双向互作的重要理念，为肺动脉高压疾病诊断与治疗提供了新的靶标，并提示肺动脉高压患者认知功能异常早期诊断与干预的重要性。该研究成果于7月29日在线发表于国际权威刊物American Journal of Respiratory and Critical Care Medicine（论文的通讯作者为同济大学附属同济医院郑加麟教授、夏骁寰研究员，第一作者为同济大学附属上海市肺科医院袁平副研究员等）。
参考资料
38人！基金委医学科学部公布一项目评审专家名单.今日头条.2023-06-19
同济大学附属同济医院郑加麟、夏骁寰团队发现肺动脉高压影响认知功能.今日头条.2022-08-03