焦雨铃(中国科学院遗传与发育生物学研究所任研究员)

焦雨铃，男，博士、研究员、博士生导师。2001年，北京大学理学学士；2003年，耶鲁大学理学硕士；2006年，耶鲁大学哲学博士；2006年-2010年，加州理工学院从事博士后研究；2010年至今，遗传与发育生物学研究所任研究员。2015年中国科学院大学教授。兼任中国细胞学会理事、植物器官发生分会会长、青年工作委员会副主任，国际拟南芥研究执委会理事、中国代表等。先后入选中科院“百人计划”（终期评估优秀）、中组部“万人计划”青年拔尖人才和领军人才、科技部“中青年科技创新领军人才”、伦敦皇家自然知识促进学会“艾萨克·牛顿高级学者”；获国家自然科学基金委员会“优秀青年基金”“国家杰出青年基金”资助；先后担任973青年项目、国家重点研发计划项目首席科学家；并获中国青年科技奖、CSPB杰出青年科学家奖、中源协和生命医学奖等奖项。担任《植物学报》《植物生理学报》、Plant Cell、in silico Plants及Journal of Plant Research编委，Quantitative Plant Biology和Frontiers in Plant Science – Plant Development \u0026 EvoDevo 副主编。

人物生平

教育经历

工作经历

个人领域

研究领域

本实验室综合转录组分析、活体成像、分子遗传学、数学建模等方法，研究植物器官发生，并应用于小麦穗型的分子设计。

1.叶片扁平化的建立机制：叶片是最基本的植物器官，通常是主要的光合作用场所。扁平宽大的形态有利于增大光合作用的面积，是常见的叶片特征。叶片的扁平化生长是伴随叶片发育过程逐渐形成的。本实验室的研究关注扁平化建立的调控机制，特别是植物激素生长素与生物力学在扁平化建立过程的作用。

2.干细胞团的重建：叶片的基部（叶腋处）能够形成新的干细胞团和分生组织，称为侧生分生组织。侧生分生组织产生侧芽，使植物能够产生分枝。开花后侧生分生组织形成花序分枝。因此，侧生干细胞的活性是决定小麦等作物关键农艺性状穗数、穗粒数的重要因素。本实验室通过活体成像、转录谱分析、以及遗传分析研究侧生干细胞团重建的转录调控网络。

3. 植物人工染色体：合成生命是生命科学的新前沿。物理学家理查德·费曼说过：“What I cannot create, I do not understand”。在细菌、酵母中，科学家已经获得了完全人工合成的染色体，不仅深化了对基因组的认识，更为快速进化、重编程代谢通路提供了技术平台。在更为复杂的多细胞生物中，人工合成基因组尚未突破。本实验室与合作者力图在植物中建立基因组操作的技术体系，实现突破。

个人成果

发表论文

[1] 曹秀卫, 杜青伟, 郭亚鹤, 汪颖, 焦雨铃. Condensation of STM is critical for shoot meristem maintenance and salt tolerance in Arabidopsis. Molecular Plant[J]. 2023, 16(9): 1445-1459,

[2] Peng, Ziyuan, Jiao, Yuling, Wang, Ying. Morphogenesis of leaves: from initiation to the production of diverse shapes. BIOCHEMICAL SOCIETY TRANSACTIONS[J]. 2023, 513-525, http://dx.doi.org/10.1042/BST20220678.

[3] Guan, Chunmei, Qiao, Lingxia, Xiong, Yuanyuan, Zhang, Lei, Jiao, Yuling. Coactivation of antagonistic genes stabilizes 极性 patterning during shoot organogenesis. SCIENCE ADVANCES[J]. 2022, 8(23): eabn0368-, http://dx.doi.org/10.1126/sciadv.abn0368.

[4] Mo, Yajin, Jiao, Yuling. Advances and applications of single-cell omics technologies in plant research. PLANT JOURNAL[J]. 2022, 110(6): 1551-1563, http://dx.doi.org/10.1111/tpj.15772.

[5] Peng, Ziyuan, Alique, Daniel, Xiong, Yuanyuan, Hu, Jinrong, Cao, Xiuwei, Lu, Shouqin, Long, Mian, Wang, Ying, Wabnik, Krzysztof, Jiao, Yuling. Differential growth 动力学 control aerial organ geometry. CURRENT BIOLOGY[J]. 2022, 32(22): 4854-4868, http://dx.doi.org/10.1016/j.cub.2022.09.055.

[6] Wang, Yuange, Du, Fei, Wang, Jian, Wang, Ke, Tian, Caihuan, Qi, Xiaoquan, Lu, Fei, Liu, Xigang, Ye, Xingguo, Jiao, Yuling. Improving bread wheat yield through modulating an unselected AP2/ERF gene. NATURE PLANTS[J]. 2022, 8(8): 930-939, http://dx.doi.org/10.1038/s41477-022-01197-9.

[7] Wang, Qingqing, Marconi, Marco, Guan, Chunmei, Wabnik, Krzysztof, Jiao, Yuling. Polar auxin transport modulates early leaf flattening. Proceedings of the National Academy of Sciences of the United States of America[J]. 2022, 119(50): e2215569119-, https://doi.org/10.1073/pnas.2215569119.

[8] Xueren Hou, Depeng Wang, Zhukuan 成姓, Ying Wang, Yuling Jiao. A near-complete assembly of an Arabidopsis thaliana genome. MOLECULAR PLANT[J]. 2022, 15(8): 1247-1250, http://dx.doi.org/10.1016/j.molp.2022.05.014.

[9] Yang, Tingting, Jiao, Yuling, Wang, Ying. Stem Cell Basis of Shoot Branching. PLANT AND CELL PHYSIOLOGY. 2022

[10] Xi Zhang, Yi Man, Xiaohong 壮族, Jinbo Shen, Yi Zhang, Yaning Cui, Meng Yu, Jingjing Xing, Guangchao Wang, Na Lian, Zijian Hu, Lingyu Ma, Weiwei Shen, Shunyao Yang, Huimin Xu, Jiahui Bian, Yanping Jing, Xiaojuan Li, Ruili Li, Tonglin Mao, Yuling Jiao, Sodmergen, Haiyun Ren, Jinxing Lin. Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(9): 1392-1422, http://apps.webofknowledge.com/CitedFullRecord.doproduct=UA\u0026colName=WOS\u0026SID=5CCFccWmJJRAuMzNPjj\u0026search_mode=CitedFullRecord\u0026isickref=WOS:000649234900001.

[11] Jiao, Yuling, Du, Fei, Traas, Jan. The Mechanical Feedback Theory of Leaf Lamina Formation. TRENDS IN PLANT SCIENCE. 2021, 26(2): 107-110, http://dx.doi.org/10.1016/日本烟草产业plants.2020.11.005.

[12] Yuanyuan Xiong, Binbin Wu, Fei Du, Xiaolu Guo, Caihuan Tian, Jinrong Hu, Shouqin L, Mian Long, Lei Zhang, Ying Wang, Yuling Jiao. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy. MOLECULAR PLANT[J]. 2021, 14(6): 949-962,

[13] Xu, Mengxue, Du, Qingwei, Tian, Caihuan, Wang, Ying, Jiao, Yuling. Stochastic gene expression drives mesophyll protoplast regeneration. SCIENCE ADVANCES[J]. 2021, 7(33):

[14] Fei Du, Feng Zhao, Jan Traas, Yuling Jiao. Visualization of cortical microtubule networks in plant cells by live imaging and immunostaining. STAR PROTOCOLS[J]. 2021, 2(1): 100301-, http://dx.doi.org/10.1016/j.xpro.2021.100301.

[15] Peter Denolf, Shaoshan Carol Huang, Kenneth D Birnbaum, Elsa H QuezadaRodrguez, Maite SauraSanchez, Kerstin Kaufmann, Luigi F Di Costanzo, Marc Libault, Fabio GomezCano, Toshihiro Obata, Naomi Nakayama, Steven P Briggs, R Clay Wright, Jennifer AN Brophy, Alexander T Borowsky, Marisa S Otegui, Nicholas J Provart, Jamie Waese, Andrey V Malkovskiy, David W Ehrhardt, Suryatapa Ghosh Jha, Selena L Rice, Seung Y Rhee, Purva Karia, Moises ExpositoAlonso, Sagar Kumar, R Glen Uhrig, Gergo Palfalvi, Noah Fahlgren, Amir H Ahkami, Christopher R Anderton, Dae Kwan Ko, Benjamin J Cole, Andrew Farmer, Pinky Agarwal, Rajveer Singh, Klaas Van Wijk, Stefania Giacomello. Vision, challenges and opportunities for a Plant Cell Atlas. ELIFE[J]. 2021, 10: http://dx.doi.org/10.7554/eLife.66877.

[16] He Zhang, Zhonglong Guo, Yan Zhuang, Yuanzhen Suo, Jianmei Du, Zhaoxu Gao, Jiawei pan, Li Li, Tianxin Wang, Liang Xiao, Genji Qin, Yuling Jiao, Huaqing Cai, Lei Li. MicroRNA775 regulates intrinsic leaf size and reduces cell wall 果胶 levels by targeting a galactosyltransferase gene in Arabidopsis. THE PLANT CELL. 2021, 33(3): 581-602,

[17] Cao, Xiuwei, Jiao, Yuling. Control of 细胞 fate during axillary meristem initiation. CELLULAR AND MOLECULAR LIFE SCIENCESnull. 2020, 77(12): 2343-2354, http://dx.doi.org/10.1007/s00018-019-03407-8.

[18] 王泓力, 焦雨铃. 染色质免疫共沉淀实验方法. 植物学报[J]. 2020, 55(4): 475-480, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ\u0026dbname=CJFDLAST2020\u0026filename=ZWXT202004009\u0026v=Mjk3MDRlckc0SE5ITXE0OUZiWVI4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjd1Zlp1WnJGeXJuVjc3TFB6clQ=.

[19] Du, Fei, Mo, Yajin, Israeli, Alon, Wang, Qingqing, Yifhar, Tamar, Ori, Naomi, Jiao, Yuling. Leaflet initiation and blade expansion are separable in 化合物 leaf development. PLANT JOURNAL[J]. 2020, 104(4): 1073-1087, http://dx.doi.org/10.1111/tpj.14982.

[20] Cao, Xiuwei, Wang, Jin, Xiong, Yuanyuan, Yang, Haibian, Yang, Minglei, Ye, Peiyi, Bencivenga, Stefano, Sablowski, Robert, Jiao, Yuling. A Self-Activation Loop Maintains Meristematic Cell Fate for Branching. CURRENT BIOLOGY[J]. 2020, 30(10): 1893-+, http://dx.doi.org/10.1016/j.cub.2020.03.031.

[21] Guo, Yahe, Tian, Caihuan, Jiao, Yuling, Wang, Ying. Multifaceted functions of auxin in vegetative axillary meristem initiation. JOURNAL OF GENETICS AND GENOMICS[J]. 2020, 47(9): 591-594, http://dx.doi.org/10.1016/j.jgg.2020.10.001.[22] Yu, ShiXia, Zhou, LvWen, Hu, LiQin, Jiang, YuTong, Zhang, YanJie, Feng, ShiLiang, Jiao, Yuling, Xu, Lin, Lin, WenHui. Asynchrony of ovule primordia initiation in Arabidopsis. DEVELOPMENT[J]. 2020, 147(24): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774900/.

[23] Du, Fei, Jiao, Yuling. Mechanical control of plant morphogenesis: concepts and progress. CURRENT OPINION IN PLANT BIOLOGYnull. 2020, 57: 16-23, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA\u0026colName=WOS\u0026SID=5CCFccWmJJRAuMzNPjj\u0026search_mode=CitedFullRecord\u0026isickref=WOS:000600745300004.

[24] Yuling Jiao. Interplay娱乐 between the shoot apical meristem and lateral organs.. aBIOTECH. 2020,

[25] Zhou, Luwen, Du, Fei, Feng, Shiliang, Hu, Jinrong, Lu, Shouqin, Long, Mian, Jiao, Yuling. Epidermal restriction confers robustness to organ shapes. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2020, 62(12): 1853-1867, http://天秤座cqvip.com/Qikan/Article/Detail?id=7103653156.

[26] Wang, Ying, Jiao, Yuling. Keeping leaves in shape. NATURE PLANTSnull. 2020, 6(5): 436-437, http://dx.doi.org/10.1038/s41477-020-0660-0.

[27] Yuling Jiao. Multinational Arabidopsis Steering Committee. (2020) Current status of the multinational Arabidopsis community.. Plant Direct. 2020,

[28] Yuling Jiao. Live imaging of Arabidopsis axillary meristems.. Methods in Molecular Biology. 2020,

[29] 杜斐, 焦雨铃. WUSCHEL介导的固有免疫：植物干细胞抵御病毒侵害的新机制. 植物学报[J]. 2020, 55(5): 537-540, http://lib.cqvip.com/Qikan/Article/Detail?id=7103368337.

[30] Hong, ShinYoung, BotterwegParedes, Esther, Doll, 素馨属, Eguen, Tenai, Blaakmeer, Anko, Matton, Sanne, Xie, Yakun, Lunding, Bjorg Skjoth, Zentgraf, Ulrike, Guan, Chunmei, Jiao, Yuling, Wenkel, Stephan. Multi-level analysis of the interactions between REVOLUTA and MORE AXILLARY BRANCHES 2 in controlling plant development reveals parallel,independent and antagonistic functions. DEVELOPMENT[J]. 2020, 147(10): http://dx.doi.org/10.1242/dev.183681.

[31] Zhao, Feng, Du, Fei, Oliveri, Hadrien, Zhou, Luwen, Ali, Olivier, Chen, Wenqian, Feng, Shiliang, Wang, Qingqing, Lu, Shouqin, Long, Mian, Schneider, Rene, Sampathkumar, Arun, Godin, Christophe, Traas, Jan, Jiao, Yuling. Microtubule-Mediated Wall Anisotropy Contributes to Leaf Blade Flattening. CURRENT BIOLOGY[J]. 2020, 30(20): 3972-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575199/.

[32] Ying Wang, Yuling Jiao. 纤维素 Microfibril-Mediated Directional Plant Cell Expansion: Gas and Brake. MOLECULAR PLANT[J]. 2020, 13(12): 1670-1672, http://天秤座cqvip.com/Qikan/Article/Detail?id=7104154253.

[33] Zhou, Yao, Zhao, Xuebo, Li, Yiwen, Xu, Jun, Bi, Aoyue, Kang, Lipeng, Xu, Daxing, Chen, Haofeng, Wang, Ying, Wang, Yuange, Liu, Sanyang, Jiao, Chengzhi, Lu, Hongfeng, Wang, Jing, Yin, Changbin, Jiao, Yuling, Lu, Fei. Triticum 种群 sequencing provides insights into wheat 适应 NATURE GENETICS[J]. 2020, 52(12): 1412-1422, http://dx.doi.org/10.1038/s41588-020-00722-w.

[34] Jiao, Yuling. May the Force Be with You: Overlooked Mechanical Signaling. MOLECULAR PLANT[J]. 2019, 12(4): 464-466, http://sciencechina.cn/gw.jsp?action=detail.jsp\u0026internal_id=6477891\u0026detailType=1.

[35] Guan Chunmei, Du Fei, Xiong Yuanyuan, Jiao Yuling. The 35S 助催化剂‐driven mDII auxin control sensor is uniformly distributed in leaf primordiaFA. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2019, 61(11): 1114-1120, http://天秤座cqvip.com/Qikan/Article/Detail?id=7100259316.

[36] Guan, Chunmei, Du, Fei, Xiong, Yuanyuan, Jiao, Yuling. The 35S 助催化剂driven mDII auxin control sensor is uniformly distributed in leaf primordia. JOURNAL OF INTEGRATIVE PLANT BIOLOGY. 2019, 61(11): 1114-1120, http://dx.doi.org/10.1111/jipb.12853.

[37] Jiao, Yuling. Designing Plants: Modeling Ideal Shapes. MOLECULAR PLANT[J]. 2019, 12(2): 130-132, http://天秤座cqvip.com/Qikan/Article/Detail?id=7001637074.

[38] Chunmei Guan, Fei Du, Yuanyuan Xiong, Yuling Jiao. The 35S 助催化剂driven mDII auxin control sensor is uniformly distributed in leaf primordia^FA. 植物学报:英文版[J]. 2019, 61(11): 1114-1120, http://lib.cqvip.com/Qikan/Article/Detail?id=7100259316.

[39] Xiong, Yuanyuan, Jiao, Yuling. The Diverse Roles of Auxin in Regulating Leaf Development. PLANTS-BASELnull. 2019, 8(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA\u0026colName=WOS\u0026SID=5CCFccWmJJRAuMzNPjj\u0026search_mode=CitedFullRecord\u0026isickref=WOS:000481484800050.

[40] Tian, Caihuan, Wang, Ying, Yu, Haopeng, He, Jun, Wang, Jin, Shi, Bihai, Du, Qingwei, Provart, Nicholas J, Meyerowitz, Elliot M, Jiao, Yuling. A gene expression map of shoot domains reveals regulatory mechanisms. NATURE COMMUNICATIONS[J]. 2019, 10(1): https://doaj.org/article/d2ca3532319b4b249fdb3dc76d4dc19b.

[41] Yuling Jiao. May the Force Be with You: Overlooked Mechanical Signaling. 分子植物:英文版[J]. 2019, 12(4): 464-466, http://lib.cqvip.com/Qikan/Article/Detail?id=7001970876.

[42] Yuling Jiao. Designing Plants: Modeling Ideal Shapes. 分子植物英文版. 2019, 12(2): 130-132, http://天秤座cqvip.com/Qikan/Article/Detail?id=7001637074.

[43] Yuanyuan Xiong, Yuling Jiao. The Diverse Roles of Auxin in Regulating Leaf Development. PLANTS[J]. 2019, 8(7): https://doaj.org/article/d22c40568b324c338cec7650d57eb5bb.

[44] Zhang, Cui, Wang, Jin, Wenkel, Stephan, Chandler, John W, Werr, Wolf Gang, Jiao, Yuling. Spatiotemporal control of axillary meristem formation by interacting transcriptional regulators. DEVELOPMENT[J]. 2018, 145(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000454696700005.[45] Yuling Jiao. Auxin and DORNRÖSCHEN joint force in the shoot apex.. Science China Life sciences. 2018, [46] Fei Du, Chunmei Guan, Yuling Jiao. Molecular Mechanisms of Leaf Morphogenesis. 分子植物：英文版[J]. 2018, 11(9): 1117-1134, http://lib.cqvip.com/Qikan/Article/Detail?id=676680660.

发表著作

（1） Insights on plant development using NGS technologies., Caister Academic, 2014-01, 第 2 作者

（2）聚焦基因, 人民教育出版社, 2018-01, 第 2 作者

科研活动

（ 1 ）拟南芥花发育早期细胞水平转录谱的研究, 主持, 国家级, 2012-01--2015-12

（ 2 ）植物表观遗传调控及其在重要发育过程中的作用机制及结构基础研究, 主持, 国家级, 2012-01--2016-08

（ 3 ）小麦高效性状分子模块系统解析, 主持, 部委级, 2013-08--2018-07

（ 4 ）系统解析侧生分生组织形成的调控网络, 主持, 国家级, 2015-01--2019-12

（ 5 ）叶片发育极性建成的调控网络研究, 主持, 国家级, 2014-01--2018-08

（ 6 ）遗传学与生物信息学, 主持, 国家级, 2013-01--2015-12

（ 7 ）万人计划青年拔尖人才, 主持, 国家级, 2015-01--2017-12

（ 8 ）器官发育的遗传与生物力学调控, 主持, 国家级, 2019-01--2023-12

（ 9 ）生长素对叶片形态建成的调控机理, 主持, 国家级, 2018-10--2021-09

（ 10 ）侧生分生组织形成的细胞水平调控, 主持, 国家级, 2018-03--2021-02

（ 11 ）伦敦皇家自然知识促进学会艾萨克·牛顿高级学者，Cellular-level regulation of axillary meristem formation, 主持, 研究所（学校）, 2018-03--2021-02

（ 12 ）叶片三维形态的力学调控, 主持, 部委级, 2019-01--2023-12

（ 13 ）中青年科技创新领军人才, 主持, 国家级, 2018-01--2020-12

（ 14 ）植物人工染色体的设计与合成, 主持, 国家级, 2020-01--2024-12

（ 15 ）单细胞多维组学分析技术, 参与, 部委级, 2019-11--2024-12

社会兼职

2020-01-01-2023-12-31,中国细胞学会青年工作委员会, 副主任

2020-01-01-2023-12-31,中国细胞学会植物器官发生分会, 会长

2020-01-01-2023-12-31,中国细胞学会信号转导分会, 委员

2020-今，Quantitative Plant Biology，副主编

2018-07-01-今,Arabidopsis Biological Resource Center Advisory Committee, Member

2016-07-01-今,Multinational Arabidopsis Steering Committee, 中国代表

2015-12-31-2019-12-31,中国细胞学会植物器官发生分会, 副会长

2013-09-01-今,中国遗传学会发育遗传专业委员会, 委员

2013-09-01-今,中国植物生理与植物分子生物学学会青年工作委员会, 委员

2013-01-01-今,国家植物基因研究中心（北京）, 项目科学家

所获荣誉

（1） CSPB 杰出青年科学家奖, 其他, 2019

（2）中国青年科技奖, 国家级, 2019

（3）中源协和生命医学奖“创新科学突破奖”, 其他, 2018

（4）益海嘉里优秀导师奖, 研究所（学校）, 2014

（5） SCOPE青年科学之星，生命科学组, 三等奖, 其他, 2013

（6） Nicholas Prize, , 研究所（学校）, 2006

（7）国家优秀自费留学生奖, , 国家级, 2005

参考资料

遗传发育所等提出解释叶片起源的“应力反馈学说”.中国科学院.2024-03-25

焦雨铃.中国科学院遗传与发育生物学研究所.2024-03-25

焦雨铃.北京大学生命科学学院.2024-09-08

叶片为什么是扁平的?.科学网.2024-03-26

焦雨铃