管吉松，男，现任上海科技大学生命科学与技术学院博士生导师。
课题组简介
研究方向
学习记忆的神经编码与细胞环路机制。
研究内容
探索哺乳动物大脑中的记忆存储和提取背后的编码规律和机制。
（1）开发大规模单神经元解析度的在体成像技术，寻找和追踪记忆活动和多模态信息存储；
（2）解析记忆神经环路以及其表观遗传调控；
（3）利用脑机接口等工程与医学手段，探索对脑损伤、脑疾病的修复治疗新方法。
研究成果展示
通过大规模神经活动信号在体内记录的方法揭示了特异性场景记忆储存在稀疏分布的皮层II层神经元中。基于皮层环路的神经环路结构，提出了新的记忆介导的认知模型。针对记忆印迹神经元深入研究，发现了SUV39H1、HDAC2等调控因子在神经元活动后诱发的表观遗传过程中的作用，确立了记忆稳定性的调控机制。融合人工智能技术，发展新型脑机接口，以用于记忆损伤相关疾病的诊断和治疗。部分成果发表在国际顶级杂志上（包括《自然》、《细胞》、《Nature 神经科学》和《美国国家科学院院刊》等）。
代表性论文
1. Guan, Ji-Song*; Haggarty, Stephen J.; Giacometti, Emanuela; Dannenberg, Jan-Hermen; Joseph, Nadine; Gao, Jun; Nieland, Thomas J. F.; Zhou, Ying; Wang, Xinyu; Mazitschek, Ralph; Bradner, James E.; DePinho, Ronald A.; Jaenisch, Rudolf; Tsai, Li-Huei .HDAC2 negatively regulates memory formation and synaptic plasticity.NATURE. 2009. 459(7243):55-U58.
2. Xie, Hong*; Liu, Yu; Zhu, Youzhi; Ding, Xinlu; Yang, Yuhao; Guan, Ji-Song .In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(7):2788-2793.
3. Guan, Ji-Song *; Xie, Hong; Ding, XinLu.The role of epigenetic regulation in learning and memory.EXPERIMENTAL NEUROLOGY. 2015. 268:30-36.
4. Zhu, Tao*; Liang, Chen; Li, Dongdong; Tian, 苗族苗族; Liu, 苯乙烯-丙烯腈共聚物xiong; Gao, Guanjun; Guan, Ji-Song .Histone 甲基transferase Ash1L mediates activity-dependent repression of neurexin-1 alpha.SCIENTIFIC REPORTS. 2016. 6.
5. Guan, Ji-Song *; Jiang, Jun; Xie, Hong; Liu, Kai-Yuan.How Does the Sparse Memory "Engram" Neurons Encode the Memory of a Spatial-Temporal Event?.FRONTIERS IN NEURAL Circuits 2016. 10.
6. Ding, Xinlu*; Liu, Sanxiong; Tian, Miaomiao; Zhang, Wenhao; Zhu, Tao; Li, Dongdong; Wu, Jiawei; Deng, HaiTeng; Jia, Yichang; Xie, Wei; Xie, Hong; Guan, Ji-Song .Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.NATURE 神经科学 2017. 20(5):6900.
7. Jiang, Jun*; Wang, Guang-Yu; Luo, Wenhan; Xie, Hong; Guan, Ji-Song .Mammillary body regulates state-dependent fear by alternating cortical oscillations.SCIENTIFIC REPORTS. 07 Sep 2018. 8.
8. Fu, Ruxing*; Luo, Wenhan; Nazempour, Roya; Tan, Daxin; Ding, He; Zhang, Kaiyuan; Yin, Lan; Guan, Jisong ; Sheng, Xing .Implantable and Biodegradable Poly(L-lactic acid) Fibers for Optical Neural Interfaces.ADVANCED OPTICAL MATERIALS. 05 Feb 2018. 6(3).
9. Zhang, Jing*; Liu, Xiaojun; Xu, Wenjing; Luo, Wenhan; Li, Ming; Chu, Fangbing; Xu, Lu; Cao, Anyuan; Guan, Jisong; Tang, Shiming; Duan, Xiaojie .Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in vivoNANO LETTERS. May 2018. 18(5):2903-2911.
10. Zhao, Yu*; Liu, Changbo; Liu, Zhixiang; Luo, Wenhan; Li, Lizhu; Cai, Xue; Liang, 越南盾; Su, Yuanzhe; Ding, He; Wang, Qiang; Yin, Lan; Guan, Jisong; Luo, Minmin; Sheng, Xing .Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals.IEEE TRANSACTIONS ON ELECTRON DEVICES. Jan 2019. 66(1):785-792.
11. Li, Dong*; Zavaglia, Melissa; Wang, Guangyu; Xie, Hong; Hu, Yi; Werner, Rene; Guan, Ji-Song; Hilgetag, Claus C. .Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning.SCIENTIFIC REPORTS. 15 May 2019. 9.
12. Li, 越南盾*; Wang, Guangyu; Xie, Hong; Hu, Yi; Guan, Ji-Song ; Hilgetag, Claus C. .Multimodal Memory Components and Their Long-Term 动力学 Identified in Cortical Layers II/III but Not Layer V.FRONTIERS IN INTEGRATIVE 神经科学 01 Oct 2019. 13(54).
13. Wang, Guangyu*; Xie, Hong; Wang, Lun; Luo, Wenhan; Wang, Yixiang; Jiang, Jun; Xiao, Chun; Xing, Feng; Guan, Ji-Song .Switching From Fear to No Fear by Different Neural Ensembles in Mouse Retrosplenial Cortex.CEREBRAL CORTEX. Dec 2019. 29(12):5085-5097.
14. Liu, Shiguo*; Tian, Miaomiao; He, Fan; Li, Jiani; Xie, Hong; Liu, Wenmiao; Zhang, Yeting; Zhang, Ru; Yi, Mingji; Che, Fengyuan; Ma, Xu; Zheng, Yi; Deng, Hao; Wang, Guiju; Chen, Lang; Sun, Xue; Xu, Yinglei; Wang, Jingli; Zang, Yucui; Han, Mengmeng; Wang, Xiuhai; Guan, Hongzai; Ge, Yinlin; Wu, Chunmei; Wang, Haiyan; Liang, Hui; Li, Hui; Ran, Ni; Yang, Zhaochuan; Huang, Huanhuan; Wei, Yanzhao; Zheng, Xueping; Sun, Xiangrong; Feng, Xueying; Zheng, Lanlan; Zhu, Tao; Luo, Wenhan; Chen, Qinan; Yan, Yuze; Huang, Zuzhou; Jing, Zhongcui; Guo, Yixia; Zhang, Xuzhan; Schaaf, Christian P.; Xing, Jinchuan; Wang, Chuanyue ; Yu, Fuli ; Guan, Ji-Song .Mutations in ASH1L confer susceptibility to Tourette SyndromeMOLECULAR PSYCHIATRY. Feb 2020. 25(2):476-490.
参考资料
管吉松.上海科技大学生命科学与技术学院.2022-01-25